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Living beings that do not originate from the planet Earth.
Alien Invasion Movies
If you want to make a modern sci-fi adventure story, what is bigger than a full-scale war with an alien race? There is the tension and excitement of an unheard of enemy, the link to everyday life that people can relate to, the chance to keep the movie from dealing with real life wars, and the chance for amazing visuals.
According to Box Office Mojo, this is one of the most consistently successful genres, though it has lost a bit of its clout in recent months.
Examples: The War of the World films, Independence Day, Skyline, and Battle: Los Angeles
Alien becomes a Super-Hero
Everyone has felt out of place and disconnected from their peers. They feel like they have special gifts and talents no one else can see, and they feel like they don't fit in. What better metaphor for this than an alien with alien powers living life among ordinary humans. After all, it makes for a great action story.
Examples: The Superman films, I Am Number Four, Thor
Space Travel Epic
Fantasy worlds tend to involve swords and dragons, but for a futuristic take on these Tolkein-esque realms, most filmmakers journey into space. Substitute Vulcans for elves and Ewoks for hobbits.
Examples: The Star Wars films, the Star Trek universe
Monsters from Demonic Dimensions
There are some forces that are meant to played with, and there are some doors that aren't meant to be opened. Such as demonic forces and gateways to hell.
Examples: Hellboy, Dylan Dog: Dead of Night, 1-11-11