The creation of John Walsh, America's Most Wanted allows viewers to take justice into there own hands. Each week viewers are introduced to several real life criminals and asked if they can provide information leading to there capture.
| John Walsh | Himself - Host | 175 eps. | |
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Don LaFontaine | Announcer | 70 eps. |
| Patrick Michael Strange | Safety Segment - House Party Guest | 35 eps. | |
| David Sontag | Truck driver | 27 eps. | |
| Wes Johnson | Prescott Sigmund | 20 eps. | |
| David L. Gandy | Hotline Operator | 17 eps. | |
| Chad Tyler | Hotline Operator | 14 eps. | |
| Jacque Temple | Safety Segment - House Party Guest | 14 eps. | |
| Michael J. Shapiro | Hotline operator | 12 eps. | |
| John Celia | Hotline Operator | 10 eps. |