Before Laurence Fishburne was cast as Dr. Raymond Langston, John Malkovich and Kurt Russell were considered for the role.
2000 fans sent a dollar bill to show producers as a part of the "Dollar for Sense" campaign to save Jorja Fox from being fired over contract disagreements.
George Eads, Jorja Fox and Marg Helgenberger have all previously appeared on "ER".
Gil Grissom and Catherine Willows are loosely based on real-life CSIs Daniel Holstein and Yolanda McCrery.
A photo of series producer Jerry Bruckheimer has appeared in numerous locations in Grissom's office.
The show has been credited with a massive increase in applications to real life forensic science courses.