"It's Not What It Looks Like!"

When Coilette is having dinner with Flexo and Bender confronts them.

A number of characters walk in on House and a therapist with his pants down when she was massaging his injured thigh. House says the phrase during this.

After Ryan noticed that he stole a bunch of stuff from his neighborhood while blacked out from his high, he says the phrase when Jenna and a bunch of disgruntled neighbors show up on his doorstep.