Agent-in-Charge of the Behavioural Science Unit of the FBI.
He leads the investigation against The Tooth Fairy in Red Dragon where he recruits Will Graham to use his unique insight in helping assist the FBI. Later, In The Silence of the Lambs, he recruits a trainee, Clarice Starling to help in the investigation regarding the kidnapping of a Senator's daughter by the serial killer known as Buffalo Bill. Clarice is tasked by Jack to interview Dr. Hannibal Lecter and to probe Lecter's mind regarding Buffalo Bill.
| 2002 | Red Dragon | Harvey Keitel | |
| 1991 | The Silence of the Lambs | Scott Glenn | |
| 1986 | Manhunter | Dennis Farina |
| Hannibal | Laurence Fishburne |