I confess that I haven't seen the Lone Wolf And Cub series of films aside from a few snippets here and there; so far as serialized Japanese swordplay films go, I was always more of a Zatoichi guy, myself. I also haven't read the manga, although I remember stocking the Dark Horse reissues back when I used to work in a bookstore, when Frank Miller provided new cover art for the trades.
It looks like I'll have to bone up on one or the other, though, as Lone Wolf And Cub is going to return to cinemas if Kamala Films has anything to say about it: they've obtained the rights to the work and have attached Fast Five's Justin Lin to direct. The series, set in Edo-period Japan, revolves around a disgraced enforcer for the shogun, forced to roam the land with his three-year-old son as he attempts to exact vengeance on his former master. At least, that's what I'm reading on Wikipedia.
It's difficult to know how this'll work; the hiring of Lin seems to indicate that Kamala wants to make this some kind of mainstream action epic, but it's unclear how they'll do that without transitioning the action away from feudal Japan. They could go for a straight adaptation, with the obvious casting of Ken Watanabe as Lone Wolf, or they could transpose the action to modern-day Tokyo yakuza (maybe with Takeshi Kitano as the evil crime lord?), or, in the worst-case scenario, shift everything to America and have Channing Tatum run around with a baby and a gun.
The central plotline of vengeance, with a young child in tow, obviously works in any setting, but we'll have to see where Kamala chooses to go with it. David and Janet Peoples will be handling the script, which is at least a good sign; the pair wrote Twelve Monkeys, with David chipping in on the script for Blade Runner, as well. Interestingly, though, neither of the pair has a screenplay credit since the late 90's.