Larry Sanders is the host of his own talk show, The Larry Sanders Show.
Before hosting the show, he was a stand up comedian and many of the real life comedians, including Jeff Cesario, who guest star were friends with Larry in his stand up days. Before his stand up career took off, he was part of a double act with comedian, Stan Paxton (played by Eric Bogosian). Off camera, Larry is neurotic and deeply self absorbed, rarely noticing other people's problems. He relies heavily on Arthur and Beverly to deal with his problems, personal and professional. He is obsessed with the size of his ass, a frequent joke between him and Arthur. In the first season he is married to Jeanie, who leaves between the first and second seasons. During season two, he dates his ex-wife Francine who also leaves at the end of the season. After dating a number of famous women, Larry proposes to Roseanne when she helps him with his addiction to prescription drugs. Larry has a difficult relationship with the network executives, whom he dislikes but who have the power to cancel his show.