Neal Page (Steve Martin) a hard nosed marketing agent is forced into traveling a fifth the way across the country with the seemingly happy-go-lucky Del Griffith, a shower curtain ring salesman.
The film starts out with Neal Page in New York obviously in hurry to leave the city and get to his family for Thanksgiving. However, it could just not be that easy. While in New York Neal gets his a cab stolen, making the rush to the airport that much more frantic. When getting to the airport he is met with a newly familiar face Del Griffith who stole Neal's cab back in the city. Del talks Neal's ear off both on and off the plane.
Neal notices the flight is taking a bit longer than it should if they were going from JFK to O'Hara. That is because of the terrible weather in Chicago forcing the flight to land in Wichita, Kansas. Once landing in Kansas, Neil calls his wife and Dale calls a local hotel giving them a place to stay for the night. However, they're forced to stay in a one bed hotel room causing some conflict. Worse than that the room is broken into and all their money is stolen.
After the two take everything from rental cars, to trains to get to their final destination, just in time for Thanksgiving dinner.