The second Predator movie is set in a backdrop of urban drug warfare. Maverick cop Mike Harrigan(Danny Glover) goes up against a new kind of killer. But when the Feds(Gary Busey,Adam Baldwin) arrive it's clear there's more going on.
A xenomorph skull (the creature from the Alien movies) appears on the wall of the Predator's trophy room. This is nod to the 'Alien Versus Predator' 1989 comic series from Dark Horse comics, hinting the possibly of a future film crossover, which eventually did happen.