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| Karen Valentine | Alice Johnson | 113 eps. | |
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Michael Constantine | Principal Seymour Kaufman | 113 eps. |
| Lloyd Haynes | Pete Dixon | 113 eps. | |
| Denise Nicholas | Liz McIntyre | 113 eps. | |
| David Jolliffe | Bernie | 62 eps. | |
| Judy Strangis | Helen Loomis / ... | 53 eps. | |
| Heshimu | 34 eps. | ||
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Eric Laneuville | 33 eps. | |
| Howard Rice | 29 eps. | ||
| Ivor Francis | 16 eps. |
| 1 | Richie's Story | 09/17/1969 | |
| 2 | Naked Came We Into the World | 09/24/1969 | |
| 3 | Funny Boy | 10/01/1969 | |
| 4 | The Coat | 10/08/1969 | |
| 5 | The Flu | 10/15/1969 | |
| 6 | First We'll Eat, Then We'll Strike | 10/22/1969 | |
| 7 | Teacher's Dropping Out | 10/29/1969 | |
| 8 | Our Teacher Is Obsolete | 11/05/1969 | |
| 9 | Triple Date | 11/12/1969 | |
| 10 | Fathers and Sons | 11/19/1969 | |
| 11 | Alice in Blunderland | 11/26/1969 | |
| 12 | Clothes Make the Boy | 12/03/1969 | |
| 13 | Seventeen Going on Twenty-Eight | 12/10/1969 | |
| 14 | The Exchange Teacher | 12/17/1969 | |
| 15 | El Genio | 12/24/1969 | |
| 16 | Arizona State Loves You | 12/31/1969 | |
| 17 | Operation Sandpile | 01/07/1970 | |
| 18 | Play It Loose | 01/14/1970 | |
| 19 | Goodbye, Mr. Hip | 01/21/1970 | |
| 20 | Once Upon a Time There Was Air You Couldn't See | 01/28/1970 | |
| 21 | The Whole World Can Hear You | 02/11/1970 | |
| 22 | Ralph | 02/18/1970 | |
| 23 | I Love You Charlie, I Love You Abby | 02/25/1970 | |
| 24 | The New Boy | 03/04/1970 | |
| 25 | Funny Money | 03/11/1970 | |
| 26 | Just Between Friends | 03/18/1970 |
| Name | Room 222 |
| Status | Returning Series |
| Date of 1st Airing | Sept. 17, 1969 |
| Date of Last Airing | |
| Show Type | |
| Original Air Day | Monday |
| Original Air Time | |
| Show Length | 30 |
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