The series was animated in the style of artist and Silver Surfer creator Jack Kirby.
Ep. 2 The Origin of the Silver Surfer: Part 2 In the comics, the Silver Surfer did not meet Thanos until long after he was freed from Galactus. Thanos was also not responsible for unlocking the Surfer's blocked memories.
Ep. 3 The Origin of the Silver Surfer: Part 3 In the comics, Frankie Raye is a redhead who has powers similar to the Human Torch. Like the series, she did become the herald of Galactus - Nova.
Ep. 3 The Origin of the Silver Surfer: Part 3 The Silver Surfer did turn on his master Galactus in the comics, but not because of unlocked memories. It was Alicia Masters, a friend of the Fantastic Four, that helped unlock the Surfer's humanity.
Ep. 4 The Planet of Dr. Moreau Pip the troll was never a slave of the Kree Empire in the comics. Neither was any troll for that matter!
Ep. 4 The Planet of Dr. Moreau Kili the troll was created specifically for the series. She has no comic book counterpart.
Ep. 5 Learning Curve: Part 1 Drax is represented as an android with an organic mind in the series. In the comics, he is an Earthman resurrected by the god Kronos for the sole purpose of destroying Thanos.
Ep. 5 Learning Curve: Part 1 The Marvel heroes Nova and Jack of Hearts can be seen in the background as part of Nebula's crew.
Ep. 5 Learning Curve: Part 1 In this episode, Uatu is revealed as the last remaining Watcher in existence. In the comics, he is one of many and he watches the sector of space that includes Earth.
Ep. 6 Learning Curve: Part 2 Mentor reveals in this episode he is the brother of Thanos. In the comics, Mentor is Thanos' father.
Ep. 7 Innervisions Lady Chaos is the child friendly version of the Marvel Comics character Lady Death.
Ep. 7 Innervisions Gamma Jen Beth has no comic counterpart. She was created for the series.
Ep. 7 Innervisions The residents of Harmony are based on the Korbinites of the comics. Only Beta Ray Bill, who has been cybernetically enhanced, has a face like a horse. Regular Korbinites have flat faces.
Ep. 7 Innervisions In the comics, Beta Ray Bill is the protector of Korbin and wields an Asgardian hammer named Stormbreaker, similar to Thor's Mjolnir.
Ep. 10 Radical Justice The Kree warrior Ronan the Accuser can be found among the Wanderers in the crowd.
Ep. 11 The Forever War The protectors created after Adam Warlock resemble the evil Magus from the comics - the future incarnation of Adam Warlock bent on universal domination.
Ep. 11 The Forever War In the comics, the Supreme Intelligence is green, not red as portrayed in the episode.
Ep. 11 The Forever War In the comics, Adam Warlock was created on Earth to be the ultimate human.