Tilda Swinton was originally cast as Dr. Serena Kogan, but was replaced by Helena Bonham Carter quickly before principle photography began.
Cormac McCarthy's novel "The Road" and Philip K. Dick's short story novel "Do Androids Dream of Electric Sheep?" served as inspiration for the tone and atmosphere of the film. McG asked many of the cast and crew to read both of the books before production.
Terminator Salvation was released on the 25th anniversary of the release of the original film, though not on the same day.
The Guns N' Roses song "You Could Be Mine" originally appeared in Terminator 2: Judgement Day and again shows up in this film.
Screenwriters Paul Haggis, Anthony Zuiker and Jonathan Nolan all did uncredited re-writes of the film.
Actor Josh Brolin was originally offered the role of Marcus Wright, but passed on the opportunity.
Principle photography for the film lasted for 77 days.
James Cameron personally suggested Sam Worthington for a role in this film, who had just finished work on Avatar.
Christian Bale, a popular actor, had a infamous freakout on the set of this movie.
This is the first Terminator film to receive a PG-13 rating.
The film was dedicated to the memory of Stan Winston, who created the original Terminator puppets.