So Campbell Scott’s officially on to play Spidey’s dad, Richard Parker, while Julianne Nicholson’s in talks to play his mom, Mary. Since they both died long before the whole origin story with the radioactive spider they, understandably, haven’t really shown up that often in the comics. As intricate & complex as these fictional histories tend to get, of course, the couple also happened to be spies who did some missions with Wolverine back in the day (if you have 50 years of issues, every conceivable story comes up.)
Probably their biggest appearance was in a #-1 issue of one Spidey title. That happened during Marvel's Flashback month and another Spidey title's #-1 issue featured a dude named Nels Van Adder - - the Proto-Goblin. As you can guess, he was the mis-fortunate guinea pig of the Green Goblin's crazy formula.
Irrfan Khan is in talks to play a “Van Atter," an unspecified villain whose name is only a couple letters off and could, thus. likely be a re-tooled Proto-Goblin. Annie Parisse would be his wife--a character who, if she was actually in the comics, probably wouldn't even warrant an entry in the Official Marvel Handbook.
Man, I know too much about this stuff...