Jake Gyllenhaal, Tobey Maguire, Garrett Hedlund, Michael Fassbender, Alex Pettyfer, Joel Edgerton, Taylor Kitsch, Kellan Lutz, Josh Hartnett, Paul Dano, Luke Evans, Michael Pitt, Oscar Isaac, Benjamin Walker and Erryn Arkin were the actors considered to play the lead. Ultimately Jeremy Renner was cast in the role.
Matt Damon (who played Jason Bourne in the original Bourne trilogy) declined to return to the role for the fourth film unless Paul Greengrass (the director of the last two films in the orignal Bourne trilogy) returned to direct. As a result the film was re-conceived as a prequel and the search for a new director and lead actor began.