The Devil's Rejects takes place seven months after the the murders in
House Of 1,000 Corpses. In Ruggsville,
Texas, the state police under the command of Sheriff John Quincy Wydell attack the farmhouse of the
sadistic serial killers "The Firefly" family. After fatally wounding Rufus, Sheriff Wydell arrests
Mother Firefly, while
Otis Driftwood and
Baby Firefly escape from the ambush.
Tiny lurks nearby the house and also escapes. Otis and Baby call their Baby's father, the psychotic clown
Captain Spaulding, and they reunite at an isolated motel in a Texas desert. When Otis and Baby arrive, they kidnap two families of singers, and begin to use sadism and violence against the harmless persons. Meanwhile, Sheriff Wydell promises Mother Firefly that he will capture and kill the runaways, seeking revenge for the death of his brother, the Deputy George Wydell.