Robert Duvall, Gene Hackman, Robert De Niro, John Hurt, Jack Nicholson, Christopher Lloyd, John Lithgow, Sean Connery, Patrick Stewart, Lou Gosset Jr. and Jeremy Irons were all considered for the role of Hannibal Lecter. Anthony Hopkins got the role and ended up winning an Academy Award for Best Actor for it.
Michael Keaton, Kenneth Branagh and Mickey Rourke were all considered for the role of Jack Crawford before it went to Scott Glenn.
In most of the scenes in Hannibal Lecters cell there is a reflection of him or Clarice depending which way the camera is pointing
Anthony Hopkins recieved the award for Best Actor despite being on screen for less then twenty minutes of the film.
It was the third, and most recent film to win the big five academy awards: Best Actor, Best Actress, Best Director, Best Picture & Best Screenplay
Michelle Pfeiffer was offered the role of Clarice Starling, but she turned it down.